Chaojie Wang Selected Research

Naphthalimides

10/2021	Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone.
10/2021	Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
10/2021	A naphthalimide-polyamine conjugate preferentially accumulates in hepatic carcinoma metastases as a lysosome-targeted antimetastatic agent.
1/2020	A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo.
2/2017	Design, Synthesis and Evaluation of Naphthalimide Derivatives as Potential Anticancer Agents for Hepatocellular Carcinoma.
4/2011	Reactive oxygen species (ROS) accumulation induced by mononaphthalimide-spermidine leads to intrinsic and AIF-mediated apoptosis in HeLa cells.

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Chaojie Wang Research Topics

Disease

43	Neoplasms (Cancer) 01/2022 - 04/2011
14	Neoplasm Metastasis (Metastasis) 11/2021 - 01/2016
10	Hepatocellular Carcinoma (Hepatoma) 10/2021 - 12/2012
8	Stomach Neoplasms (Stomach Cancer) 04/2022 - 01/2016
5	Colorectal Neoplasms (Colorectal Cancer) 10/2021 - 01/2017
4	Esophageal Squamous Cell Carcinoma 11/2021 - 01/2019
4	Thyroid Neoplasms (Thyroid Cancer) 10/2020 - 02/2012
2	Carcinogenesis 06/2022 - 07/2018
2	Carcinoma (Carcinomatosis) 10/2021 - 01/2020
2	Experimental Melanoma 07/2008 - 08/2007
2	Leukemia L1210 07/2008 - 08/2007
2	Leukemia 11/2003 - 06/2003
1	Prostatic Neoplasms (Prostate Cancer) 01/2022
1	Lymphatic Metastasis 11/2021
1	Aortic Dissection 09/2021
1	follicular Thyroid cancer 10/2020
1	Male Infertility (Male Sterility) 04/2020
1	Dysbiosis 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Esophageal Neoplasms (Esophageal Cancer) 01/2020
1	Metaplasia 01/2020
1	Onchocerciasis 01/2020
1	Pathologic Processes 12/2018
1	Squamous Cell Carcinoma of Head and Neck 12/2018

Drug/Important Bio-Agent (IBA)

17	PolyaminesIBA 01/2022 - 11/2003
10	Pharmaceutical PreparationsIBA 01/2022 - 06/2011
8	Biological ProductsIBA 10/2021 - 06/2003
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
6	NaphthalimidesIBA 10/2021 - 04/2011
6	amonafideIBA 10/2021 - 04/2012
4	Long Noncoding RNAIBA 01/2021 - 07/2018
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 01/2017
3	CateninsIBA 10/2021 - 01/2017
3	Protein Isoforms (Isoforms)IBA 10/2020 - 08/2013
3	SpermineIBA 02/2020 - 11/2016
3	MicroRNAs (MicroRNA)IBA 01/2019 - 01/2016
3	Eflornithine (Ornidyl)FDA Link 08/2007 - 06/2003
2	Mitoxantrone (Novantrone)FDA LinkGeneric 10/2021 - 12/2012
2	EnzymesIBA 10/2021 - 01/2020
2	naphthalenediimideIBA 02/2020 - 04/2012
2	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 02/2017
2	ProdrugsIBA 12/2019 - 01/2018
2	PlatinumIBA 12/2019 - 01/2018
2	p21-Activated KinasesIBA 11/2019 - 08/2013
2	TOR Serine-Threonine KinasesIBA 12/2018 - 05/2015
2	SpermidineIBA 01/2017 - 08/2007
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2017 - 10/2016
1	Monoamine Oxidase (MAO)IBA 06/2022
1	Oxidoreductases (Dehydrogenase)IBA 06/2022
1	AminesIBA 06/2022
1	Indocyanine Green (Cardio-Green)FDA LinkGeneric 02/2022
1	Coloring Agents (Dyes)IBA 02/2022
1	N- (5- (((5- (1,1- dimethylethyl)- 2- oxazolyl)methyl)thio)- 2- thiazolyl)- 4- piperidinecarboxamideIBA 11/2021
1	flavoneIBA 10/2021
1	HMGB1 Protein (HMG1)IBA 10/2021
1	lycorineIBA 05/2021
1	RNA (Ribonucleic Acid)IBA 05/2021
1	Enhancer of Zeste Homolog 2 ProteinIBA 11/2020
1	Interleukin-6 (Interleukin 6)IBA 11/2020
1	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 10/2020
1	RacivirIBA 10/2020
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 10/2020
1	Amino Acids FDA Link 04/2020
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 04/2020
1	LipopolysaccharidesIBA 01/2020
1	Programmed Cell Death 1 ReceptorIBA 01/2020
1	spasmolytic polypeptideIBA 01/2020
1	Therapeutic UsesIBA 01/2020
1	Circular RNAIBA 01/2020
1	mitonafideIBA 01/2020
1	Antiparasitic Agents (Antiparasitics)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	ButyrylcholinesteraseIBA 01/2020
1	Tyrosine (L-Tyrosine)FDA Link 01/2020
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Ivermectin (Mectizan)FDA Link 01/2020
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2019
1	DNA (Deoxyribonucleic Acid)IBA 12/2019
1	Cisplatin (Platino)FDA LinkGeneric 12/2019
1	huachansuIBA 01/2019
1	cinobufotalinIBA 01/2019
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2019
1	Amphibian VenomsIBA 01/2019
1	adavosertibIBA 01/2019
1	midostaurinIBA 12/2018
1	CeramidesIBA 12/2018
1	Serine (L-Serine)FDA Link 12/2018
1	Threonine (L-Threonine)FDA Link 12/2018
1	Small Interfering RNA (siRNA)IBA 12/2018
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018
1	Organic Cation Transporter 2IBA 01/2018
1	arginine polyamineIBA 01/2018

Therapy/Procedure

9	Therapeutics 10/2021 - 01/2016
2	Drug Therapy (Chemotherapy) 04/2015 - 01/2013
1	Gastrectomy 04/2022
1	Immunotherapy 01/2022
1	Prostheses and Implants (Prosthesis) 09/2021
1	Stents 09/2021
1	Oral Administration 12/2018